Physical Examination • On a gynecologic examination, the external genitalia is usually normal. The cervix may be involved with cancer (Stage II), and the vagina may also be involved (Stage III). • Occasionally the uterus will be enlarged or softened and masses may be detected in the pelvis (a rectal examination is an important aspect of the pelvic examination). • Enlarged lymph nodes in the neck and groin. • Enlarged liver, abdominal mass or excessive abdominal fluid (ascites). Blood and Other Tests • Complete blood count. • Serum liver and kidney tests. • Serum CA-125 is produced by a small percentage of women with endometrial carcinoma , which can be useful in follow-up to detect recurrences.